MacFrog is back -
presenting ...

Virtual Physiology
the unique truly simulation software

physiology and pharmacology experiments
in virtual laboratories
almost like in the real world

The Virtual Laboratories:
The Virtual Physiology programs are going far beyond conventional teaching tools, offering realistically appearing, fully equipped laboratories on the computer screen for free experimentation. All stimulation and recording devices are freely adjustable. Mathematical algorithms guarantee for the appropriate reactions of the preparations in all situations, also considering their physiological diversity.

SimHeart and SimVessel feature physiological and pharmacological experi-ments with the isolated, perfused heart in the Langendorff-setup and with isolated smooth muscle strips of blood vessels (aorta) and the stomach (antrum) to examine the muscle contractions after application of physiolo-gical transmitters (Acetylcholine), hormones (Adrenaline) and diverse drugs like the competitive receptor antagonists (Atropine, Phentolamine, Propranolol) and non-competitive modulators of Ca2+-currents and Ca2+-concentrations (Verapamil, g-Strophantin). An additional “Drug Laboratory” can be used practicing the correct preparation of the requested dilutions.

SimMuscle and SimNerv offer highly realistic experimental set-ups on the computer screen to record contractions of the frog’s gastrocnemic muscle (e.g. single twitches vs. tetanic contractions, muscle fatigue, curves of isometric and isotonic maxima) or compound action potentials from the frog’s sciatic nerve (dependence on electrode positions, refractory period, anode break potentials, etc.), respectively.
SimNeuron additionally allows performing widely used voltage- and current-clamp experiments in an easy to overlook lab design for recordings of current-voltage curves (reversal potentials etc.) or the threshold of action potential generation and its dependencies on stimulus strength and duration – also under application of TTX or TEA.
Didactic Aspects:
Although the virtual laboratories have originally been considered as minor substitutes of experi­ments with animal preparations, it turned out that the virtual labs can have major didactic advantages:
- The students are doing the experiments without negative emotions from the killing of an animal and without the fear that they need to kill one more animal if they are making a mistake that destroys the preparation.
- Only in the virtual laboratories the students feel free to explore the reaction of the preparation on their own, including unconventional stimulation protocols.
- The students have the possibility studying the reactions of the virtual preparations without any time pressure - also on their computers at home.
- Technically more challenging experiments like voltage- and patch-clamp recordings, that are unfeasible to be physically carried out in students’ introductory courses, can be realized in silico with a user-friendly interface.
under construction: SimPatch II ©:

Voltage Clamp Experiments in a realistic lab environment.
Compiled for Win7 but so far still the old version in low resolution.

  • June 10, 2016:

    Virtual Physiology on exhibition at "Campus Marburg", Germany. s. Poster

  • March 3-5, 2016:

    SimHeart and SimVessel on exhibition at the Annual Meeting of the German Physiological Society (DPG). Lübeck, Germany.
    s. Poster

  • February 12, 2016:

    Heart and smooth muscle videos are now available (preliminary versions).

  • December 15, 2015:

    Recent progress of the Virtual Physiology teaching tools including corrections and extensions.

  • September 20-23, 2015:

    Virtual Physiology on exhibition at the 16th Annual Congress of EUSAAT, Linz, Austria. s. Poster

  • June 25, 2015:

    Comenius Award 2015 for SimHeart.
    Report from Sept. 1st, 2015 (in German)

  • June 13, 2015:

    Virtual Physiology on exhibition at Berlin's "Lange Nacht der Wissenschaften" Poster

  • May 24-June 15, 2015:

    Conference and lecture tour through China (Hans A. Braun) with Virtual Physiology presentations at Beihang University, Beijing, Lanzhou University of Technology, Hong Kong Baptist University and ICCN 2015 in Sanya.

  • May 22, 2015:

    Virtual Physiology new updates. Take a look on the corrections and extensions

  • March 18-21, 2015:

    Virtual Physiology on Exhibition at the Meeting of the German Neuroscience Society (NWG). Göttingen, Germany

  • March 5-7, 2015:

    Exhibition at the Annual Meeting of the German Physiological Society (DPG). Magdeburg, Germany.

  • February 20, 2015:

    Vocational training of teachers (NWG Lehrerfortbildung) with the Virtual Physiology Serie at the Physiological Institute, Univ. of Marburg. (Program)

  • January 30, 2015:

    SimNeuron 2.3.0 now with selectable features (pre-settings).

  • December 02, 2014:

    SimVessel 2.0 now available.

  • November 15-19, 2014:

    SfN Neuroscience Meeting in Washington DC ( the Virtual Physiology on exhibition with a poster (Theme H, Poster 025.04SA/VV21) and with demos at the booth of Thomas Recording (both no 2023, see also

  • September 30, 2014:

    SimVessel soon available. Take a look on the new design.

  • August 24-28, 2014:

    Virtual Physiology on exhibition at the 9th World Congress on Alternatives and Animal Use in the Life Sciences in Prag (

  • August 20, 2014:

    New versions of SimNerv 2.2.1, SimNeuron 2.2.1 and SimMuscle 2.2.1 are now available.

  • April 07, 2014:

    SimNeuron 2.2.0:
    New Features.
    SimHeart 2.2:
    Adjustment of the Verapamil and Digitalis algorithms.

  • March 13-15, 2014:

    Virtual Physiology at the 93rd German Physiological Society Meeting in Mainz ( (Poster P273).

  • March 09, 2014:

    SimNeuron with new Features for practical courses.

  • March 09, 2014:

    SimHeart upgrade is now available. Demo Versions can be downloaded.

  • November 09-13, 2013:

    SfN Neuroscience Meeting in San Diego ( the Virtual Physiology on exhibition with a poster (Theme H, Poster 021.04) and with demos at the booth of Thomas Recording (both no 1929, see also

  • October 07, 2013:

    SimHeart Demo Version is now available.

  • June 06, 2013:

    Demo Version of SimNerv can be downloaded.

  • January 29, 2013:

    Demo Versions of SimNeuron and SimMuscle are now available for download.

  • December 20, 2012:
    MacFrog congratulates KingFrog

    on the occasion of the 200th anniversary of the first release of Grimm Brothers folktales in Marburg, Dec. 20, 1812

  • Virtual Physiology Series                                                                                            by BM&T copyright© 2012-2016. All rights reserved.